Practical Organis Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis.

Features:

• Safety in the laboratory
• Environmentally responsible handling of chemicals and solvents
• Crystallisation
• Distillation
• Chromatographic methods
• Extraction and work-up
• Structure determination by spectroscopic methods
• Searching the chemical literature
• Laboratory notebooks
• Writing a report
• Hints on the synthesis of organic compounds
• Disposal and destruction of dangerous materials
• Drying and purifying solvents

Contents

Accident Prevention and First Aid

• Safety
• First Aid

Environmentally Responsible Handling of Chemicals and Solvents

• Dangerous and Poisonous Material
• Regulations
• Maximum Concentration Limits

Crystallisation

Distillation

Chromatographic Methods

• Principles
• Thin–Layer Chromatography
• Column Chromatography
• Flash Chromatography
• HPLC

Extraction and Work-Up

Structure Determination Using Spectroscopic Methods

Searching the Chemical Literature

• The Mountain of Information
• On-Line Databases
• Monographs and Handbooks
• Collections of Data

Laboratory Notebooks

Writing a Report

Example of a Laboratory Report

Hints on the Synthesis of Organic Compounds

• The Route to Success
• Handling Water and Oxygen Sensitive Substances
• Working at Low Temperatures
• Synthesis and Analysis of Optically Active Compounds
• Synthesis of Isotopically Labelled Compounds

Disposal and Destruction of Dangerous Materials

• Classification of Waste Material
• Environmentally Acceptable Substances for Treating Dangerous Materials in the Laboratory
• Special Instructions for the Destruction of the Main Classes of Dangerous Substances
• Deactivation of Unknown Laboratory Chemicals
• Waste Disposal

Purification and Drying of Solvents

• Some Drying Agents.
• Solvents

EU R and S Phrases

Index

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