Practical Preimplantation Genetic Diagnosis describes the experience of PGD, demonstrating the considerable progress made in this revolutionary procedure and describing its utility within different patient groups, the accuracy of the laboratory methods and prediction of the reproductive outcome.

Practical Preimplantation Genetic Diagnosis will be vital for clinicians to access a comprehensive description of available experience, indications, methods and clinical outcomes.

Contents

1. Primary Prevention of Genetic Disorders and Place of Preimplantation Genetic Diagnosis

2. Approaches to Preimplantation Genetic Diagnosis

• Obtaining Biopsy Material
• Single-Cell Genetic Analysis

3. Preimplantation Genetic Diagnosis for Single Gene Disorders

• Autosomal Recessive Diseases
• Autosomal Dominant Disorders
• Homozgous or Double Heterozygous Recessive Conditions
• Conditions with No Available Direct Mutation Testing
• Late-Onset Disorders with Genetic Mutations
• Blood Group Incompatibility
• Congenital Malformations
• Dynamic Mutations

4. Preimplantation HLA Typing

• PGD for Fanconi Anemia with Preimplantation HLA Matching
• Current Experience of PGD with Preimplantation HLA Matching
• Preimplantation HLA Matching Without PGD
• Worldwide Experience of Preimplantation HLA Typing

5. Preimplantation Genetic Diagnosis for Chromosomal Disorders

• Aneuploidies
• Chromosomal Rearrangements

6. Clinical Outcomes Following Preimplantation Genetic Diagnosis

7. Preimplantation Genetic Diagnosis and Establishment of Human Embryonic Stem Cell Lines

• Marfan Syndrome
• Thalassemia
• Fragile-X Syndrome
• Myontonic Dystrophy
• Neufibromatosis Type 1
• Becker Muscular Dystrophy

8. Ethical, Social, and Legal Issues

Index

click here to see books • videos • cd-roms of related interest